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. Author manuscript; available in PMC: 2017 Apr 6.
Published in final edited form as: Nat Neurosci. 2016 Sep 19;19(12):1628–1635. doi: 10.1038/nn.4392

Figure 1. DMHLepR neurons are a potent source of GABAergic input to ARCAgRP neurons.

Figure 1

(a–b), DMHvGAT neurons provide monosynaptic inhibitory input to 100% of ARCAgRP neurons (a) and ARCPOMC neurons recorded (b). (c–d), DMHLepR neurons provide selective monosynaptic input to 100% of ARCAgRP (c) but only 9% of ARCPOMC neurons recorded (d). (e), DMHLepR→ARC neurons provide dense axo-somatic innervation of ARCAgRP neurons. (f), Photostimulation of DMHLepR→ARC terminals is sufficient to inhibit ARCAgRP action potential firing. Abbreviations, 3v, third ventricle; PTX, picrotoxin. Scale bar in panel e, 100 μm and f, 25 μm.