FIG 3.

Differentiation of nonhuman primates challenged with ZIKV or DENV by specific IgG binding to E antigens. (A) Binding of convalescent-phase serum antibodies from nonhuman primates (NHPs) challenged with either an Asian (H/PF) (n = 3) (red) or African (MR-766) (n = 3) (royal blue) lineage ZIKV, or DENV (n = 4 each for the DENV1 [black], DENV2 [green], DENV3 [orange] groups; n = 3 for the DENV4 group [magenta]) to whole viruses (144 h) and E proteins. Values shown are antibody binding signals relative to the virus used for challenge (±SEM). (B) Principal-component analyses of relative IgG binding to E proteins and viruses (144 h) by NHP antibodies. Individual data points and virus-specific clusters are colored according to the challenge virus as in panel A. PC1, principal component 1.