Table 3. Loci associated with bone traits in crossbred layer population.
Chromosome | SNP | Physical positiona | Minor/major Allele | Minor Allelic Frequency | Candidate gene | SNP location | Proportion phenotypic variance | Betab | SEc | P Value | Trait |
---|---|---|---|---|---|---|---|---|---|---|---|
1 | rs312784357 | 165885243 | A/G | 0.480 | RANKL | intergenic | 0.050 | -0.298 | 0.057 | 3.09E-07 | BMC |
1 | rs312550725 | 169381724 | T/C | 0.405 | SERPINE3 | missense | 0.013 | 0.226 | 0.047 | 4.71E-08 | Breaking strength |
1 | rs317281616 | 169400244 | G/A | 0.307 | INTS6 | intron | 0.030/0.056 | 0.275/0.345 | 0.049/0.055 | 1.29E-08/5.86E-10 | Breaking work/BMC |
1 | rs13975174 | 171298203 | A/G | 0.370 | POSTN | intron | 0.077 | −0.293 | 0.050 | 2.88E-12 | Femoral weight |
4 | rs14491507 | 76073771 | A/G | 0.052 | TAPT1 | intergenic | 0.024 | 0.479 | 0.090 | 1.11E-07 | BMC |
4 | rs15620367 | 76186390 | A/G | 0.130 | FGFBP1 | intron | 0.023 | 0.333 | 0.066 | 5.51E-07 | Femoral weight |
14 | rs313699988 | 11876668 | T/C | 0.126 | GSG1L | intergenic | 0.023 | 0.315 | 0.062 | 4.18E-07 | BMD |
24 | rs315096388 | 1684374 | T/C | 0.177 | ADAMTS15 | intergenic | 0.014 | 0.215 | 0.051 | 2.43E-07 | Breaking strength |
27 | rs316237751 | 3200813 | G/C | 0.087 | SOST | intergenic | 0.031 | 0.430 | 0.071 | 1.59E-09 | BMC |
27 | rs316723909 | 3464323 | G/A | 0.087 | IGF2BP1 | intergenic | 0.041 | 0.500 | 0.072 | 5.01E-12 | Femoral weight |
aPhysical position is bp location on chromosome for NCBI Gallus_gallus-4.0. bEstimates presented for allelic substitution effect per copy of the effect allele (EA) under an additive model, expressed in SD unit/allele.
cSE is the standard error of the beta.