Table 1. Collection of structural variants leading to oncogenic fusions in different sample types.
All events are ranked into the highest category (1) by the prioritisation scheme.
| Sample | Panel or WGS | Manta call | Lumpy call | Fusion(s) |
|---|---|---|---|---|
| HDC134P rep. 1 | Panel with intronic probes | INV | INV | EML4-ALK |
| HDC134P rep. 2 | Panel with intronic probes | INV | INV | EML4-ALK |
| HDC134P rep. 3 | Panel with intronic probes | INV | BND | EML4-ALK |
| HDC140P rep. 1 | Panel with intronic probes | INV | BND | CCDC6-RET |
| HDC140P rep. 2 | Panel with intronic probes | INV | BND | CCDC6-RET |
| HDC140P rep. 3 | Panel with intronic probes | INV | BND | CCDC6-RET |
| HDC141P rep. 1 | Panel with intronic probes | BND | BND | ROS1-SLC34A2 |
| HDC141P rep. 2 | Panel with intronic probes | BND | BND | ROS1-SLC34A2 |
| HDC141P rep. 3 | Panel with intronic probes | BND | BND | ROS1-SLC34A2 |
| MCF7 | WGS | DUP | DUP | ESR1-CCDC170 |
| RT4 | Panel with intronic probes | DUP | DUP | TACC3-FGFR3 |
| PDX model | WES | DUP | DUP | TACC3-FGFR3 |
| Prostate cancer patient sample | FMI Panel with intronic probes | DEL | DEL | TMPRSS2-ERG |