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Tumor-derived exosomes in drug resistance. Resistance of tumor cells to chemotherapy may be mediated by exosomes. Cisplatin-sensitive tumor cells die and, as a result, levels of tumor-derived exosomes decrease in plasma. In contrast, cisplatin-resistant tumor cells package the drug into exosomes and export large quantities of exosomes out of the cell. Thus, the exosomal content of plasma increases.
