Table 1.
Association results for the three associated loci
| Discovery stage | Replication stage | Combined stages | Heterogeneity | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SNP | CHR | BP | Minor allele (a) | Major allele (A) | P | OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | I2 | Tau2 |
| rs10937625 | 4 | 5 128 159 | C | T | 4.42 × 10−6 | 0.80 (0.73–0.88) | 7.36 × 10−4 | 0.77 (0.66–0.90) | 5.21 × 10−10 | 0.80 (0.74–0.87) | 39.6% | 0.0049 |
| rs17590046 | 4 | 24 362 541 | C | T | 3.39 × 10−6 | 0.80 (0.73–0.88) | 6.81 × 10−4 | 0.75 (0.64–0.89) | 1.39 × 10−9 | 0.79 (0.72–0.86) | 47.6% | 0.0082 |
| rs12764057 | 10 | 68 845 715 | G | T | 3.99 × 10−5 | 1.28 (1.19–1.39) | 0.275 | 1.07 (0.94–1.22) | 1.19 × 10−8 | 1.17 (1.09–1.26) | 61.6% | 0.0089 |
| rs10822974 | 10 | 68 850 419 | G | A | 3.02 × 10−5 | 1.27 (1.18–1.37) | 0.796 | 0.98 (0.86–1.13) | 1.65 × 10−7 | 1.16 (1.08–1.24) | 67.3% | 0.0118 |
| rs7903491 | 10 | 68 917 164 | A | G | 1.10 × 10−6 | 1.20 (1.11–1.30) | 0.407 | 1.05 (0.93–1.20) | 2.49 × 10−7 | 1.10 (1.03–1.18) | 92.4% | 0.0676 |
SNP = dbSNP ID of the marker; CHR = chromosome; BP = chromosomal position (GRCh37), OR (95% CI) = odds ratio with 95% confidence interval; I2 = ratio of true heterogeneity to total observed variation; tau2 = between studies variance. Heterogeneity metrics were calculated between samples included in: discovery stage with European descent, discovery stage with North American descent, replication stage with European descent and replication stage with North American descent.