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. 2016 Oct 25;139(12):3121–3136. doi: 10.1093/brain/aww254

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© The Author (2016). Published by Oxford University Press on behalf of the Guarantors of Brain.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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IL4I1 modulates IFN-γ and IL-17 expression in CNS lesions and splenocytes. (A) Normalized expressions of Ifng, Il17 and Il4 in wild-type (WT, n = 4) and IL4I1-treated (n = 6) spinal cord lesions at 10 dpl by qRT-PCR. (B) Normalized expression of Ifng expression in splenocyte cultures treated with PMA+Ionomycin in the presence or absence of recombinant IL4I1 for 24 h (n = 3 per group) followed by qRT-PCR. (C) Cell death assay in splenocyte cultures treated with PMA+Ionomycin with or without recombinant IL4I1 for 24 h, and assessed by LIVE/DEAD^® cell stain kit (n = 8 per group).