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. 2016 Nov 5;140(1):184–200. doi: 10.1093/brain/aww270

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© The Author (2016). Published by Oxford University Press on behalf of the Guarantors of Brain.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Blood–brain barrier integrity of THY-Tau22 mice. Immunofluorescence labelling of the tight junction marker zonula occludens-1 (ZO-1; red) and the constitutive endothelial marker von Willebrand factor (VWF; green) in the CA1 region of the hippocampus of wild-type (WT; top) and THY-Tau22 mice (bottom) at 12 months of age. DAPI staining of nuclei in blue. Similar co-stainings was observed in both genotypes, reflecting an absence of major blood–brain barrier impairment in transgenic animals. n = 3/group. Scale bar = 20 µm.