. Author manuscript; available in PMC: 2017 Oct 1.

Published in final edited form as: Org Chem Front. 2016 Aug 22;3(10):1314–1318. doi: 10.1039/C6QO00215C

Table 3.

Comparison of Conditions for Chroman Synthesis^a


Entry	R	X	Yield^b
1	H	OTf	68
2	H	Br	76^c
3	OMe	OTf	41
4	OMe	Br	57^c
5	C(O)Ph	OTf	78
6	C(O)Ph	Br	51^c

Reaction Conditions for X = OTf: 1.0 equiv 1, 1.2 equiv R-OTf, 1.4 equiv LiO^tBu, 2 mol % Pd(OAc)₂, 5 mol % ligand, solvent (0.125 M), 98 °C, 16 h. Reactn Conditions for X = Br: 1.0 equiv 1, 2.0 equiv R–Br, 2.0 equiv NaO^tBu, 2 mol % Pd₂(dba)₃, 4 mol % S-Phos, toluene (0.25 M), 110 °C.

Yields are isolated yields (average of two or more experiments) of material with >95% purity.

Yields as reported in reference 12.