Table 5. Summary of the enriched GO Terms of the proteins participating in conserved PPIs.

General Process	GO Term ID	GO Term Name	# of PPIs	p-value
Cell Cycle	GO:0000070	Mitotic sister chromatid segregation	5	2.01E-11
	GO:0007049	Cell Cycle	13	1.81E-6
	GO:0007067	Mitosis	10	2.16E-11
	GO:0051301	Cell Division	12	2.15E-10
DNA Organization	GO:0007076	Mitotic chromosome condensation	3	6.14E-9
	GO:0007062	Sister chromatid cohesion	2	2.17E-6
	GO:0006310	DNA recombination	2	9.84E-4
	GO:0030261	Chromosome condensation	4	6.69E-13
Signalling	GO:0051276	Chromosome organization	3	1.21E-7
	GO:0000750	Pheromone-dependent signal transduction	7	2.18E-17
	GO:0007165	Signal transduction	7	6.48E-11
	GO:0007186	G-coupled receptor signalling pathway	3	5.76E-10
	GO:0031684	heterotrimeric G-protein complex cycle	2	8.60E-8
	GO:0019236	Response to pheromone	4	1.06E-8
Lipid Metabolism	GO:0006696	Ergosterol biosynthetic process	10	5.63E-25
	GO:0006629	Lipid metabolic process	13	1.49E-13
	GO:0006694	Steroid biosynthetic process	10	1.42E-24
Carbohydrate Metabolism	GO:0005975	Carbohydrate metabolic process	4	1.55E-5
	GO:0006098	Pentose-phosphate shunt	2	2.34E-5
Other	GO:0070058	tRNA gene clustering	3	5.76E-10
	GO:0006607	NLS-bearing substrate import into nucleus	2	3.61E-6
	GO:0006409	tRNA export from nucleus	2	3.61E-6

GO Term (process) enrichment grouped by category of proteins involved in interactions which were conserved across the 5 yeast species studied here. These interactions were also not present in any of the simulated interactomes. GO IDs were common to both proteins participating in the interaction.