Table 2. LD-score regression and GCTA results for SCDC scores in ALSPAC.
| SCDC score |
LD score regression |
GCTAa |
|||||
|---|---|---|---|---|---|---|---|
| Unconstrainedb | Constrainedc | λGC | Mean χ2 | N | h2(SE)a | Nd | |
| Intercept(SE) | h2(SE) | ||||||
| 8 y | 0.992 (0.0067) | 0.19 (0.06) | 1.023 | 1.022 | 5553 | 0.24 (0.07) | 5137 |
| 11 y | 1.000 (0.0065) | 0.17 (0.07) | 1.014 | 1.019 | 5462 | 0.17 (0.07) | 5058 |
| 14 y | 0.988 (0.0067) | 0.08 (0.06) | 1.005 | 1.009 | 5060 | 0.08 (0.07) | 4735 |
| 17 y | 1.009 (0.0070) | 0.30 (0.11) | 1.029 | 1.025 | 4175 | 0.45 (0.08) | 3978 |
Abbreviations: ALSPAC, Avon Longitudinal study of Parents and Children; GCTA, genome-wide complex trait analysis; h2, SNP heritability; LD, linkage disequilibrium; SCDC, Social Communication Disorder Checklist; y, age at assessment in years; λGC, Genomic inflation factor.
a
Findings correspond closely to previously published estimates.27
b
LD score regression using an unconstrained intercept.
c
LD score regression constraining the intercept for the SNP-h2 estimation to one.
d
Differences compared with the total sample N are due to the exclusion of individuals with a relatedness of ≥2.5%.