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. Author manuscript; available in PMC: 2018 Apr 1.
Published in final edited form as: Dev Biol. 2017 Feb 17;424(1):77–89. doi: 10.1016/j.ydbio.2017.02.007

Figure 7. Elf3 and Ehf can also activate principal cell genes.

Figure 7

A. Elf3 and Ehf increase the transcriptional activities of mouse 1Kb Avpr2 and 1Kb Aqp2 proximal promoters in immature collecting duct cell lines. Elf3 significantly activates both principal cell gene promoter in all three immature collecting duct cell lines, with a maximum activation of the Avpr2 promoter by 28-fold and Aqp2 promoter by 21-fold in M5 cells. Ehf significantly activates both gene promoters in M5 cells and only the Avpr2 promoter in M3 cells. The asterisks denote p<0.05, n=6 per condition per cell type, unpaired t-tests.