Table 1. Effect of rs2104772 on muscle-related variables prior to endurance training.
| Parameter | ALL (n = 61) | A/A (n = 12) | A/T (n = 38) | T/T (n = 11) | p-value | T | |
|---|---|---|---|---|---|---|---|
| ALL | A | ||||||
| Age [y] | 29.5 ± 9.3 | 31.3 ± 8.3 | 27.9 ± 8.3 | 33.7 ± 12.8 | 0.199 | 0.245 | 0.877 |
| Height [cm] | 178.8 ± 6.6 | 177.5 ± 8.0 | 179.6 ± 6.5 | 177.1 ± 5.3 | 0.481 | 0.574 | 0.718 |
| Body mass [kg] | 76.5 ± 12.7 | 75.1 ± 11.8 | 76.4 ± 13.3 | 78.2 ± 12.9 | 0.868 | 0.611 | 0.640 |
| BMI [kg m–2] | 23.9 ± 3.3 | 23.7 ± 2.2 | 23.6 ± 3.3 | 25.0 ± 4.3 | 0.536 | 0.295 | 0.631 |
| Pmax [W] | 303.9 ± 38.8 | 285.4 ± 52.7 | 308.0 ± 29.9 | 303.7 ± 57.9 | 0.685 | 0.712 | 0.307 |
| VO2max [ml O2 min–1 kg–1] | 45.5 ± 8.9 | 45.1 ± 9.5 | 46.3 ± 8.0 | 43.1 ± 12.1 | 0.639 | 0.448 | 0.893 |
| Capillary-to-fiber ratio | 1.9 ± 0.6 | 1.8 ± 0.6 | 1.9 ± 0.6 | 2.0 ± 0.8 | 0.726 | 0.515 | 0.434 |
| Capillary density [mm–2] | 496.2 ± 92.5 | 513.6 ± 100.6 | 494.0 ± 98.0 | 484.6 ± 64.8 | 0.741 | 0.553 | 0.443 |
| Muscle fiber area [μm2] | 3592.7 ± 1158.7 1158.7 | 3177.1 ± 453.6 | 3633.5 ± 975.5 | 3908.8 ± 1986.5 1986.5 | 0.305 | 0.210 | 0.131 |
| Myofibrils [%] | 80.4 ± 3.1 | 79.1 ± 3.8 | 80.7 ± 2.9 | 80.7 ± 3.1 | 0.274 | 0.434 | 0.122 |
| Total mitochondria [%] | 5.2 ± 1.3 | 6.0 ± 1.4 | 5.0 ± 1.1 | 5.3 ± 1.5 | 0.054 | 0.692 | 0.047 |
| If-mitochondria [%] | 4.3 ± 0.9 | 4.7 ± 0.9 | 4.1 ± 0.8 | 4.3 ± 1.1 | 0.132 | 0.802 | 0.108 |
| Ss-mitochondria [%] | 0.9 ± 0.5 | 1.3 ± 0.7 | 0.9 ± 0.4 | 0.8 ± 0.6 | 0.039 | 0.151 | 0.013 |
| IMCL [%] | 0.6 ± 0.3 | 0.6 ± 0.4 | 0.6 ± 0.3 | 0.4 ± 0.1 | 0.124 | 0.056 | 0.412 |
| Residual organelles [%] | 13.8 ± 2.3 | 14.4 ± 3.0 | 13.7 ± 2.2 | 13.6 ± 2.0 | 0.862 | 0.558 | 0.352 |
Data refer to mean ± standard deviation (SD), sample number (n), and p-values for the effect of the rs2104772-genotype and the presence of adenosine (A) or thymidine (T) on anthropometric and muscle related parameters before endurance training. Data were assessed with an ANOVA with post hoc test of Fisher. BMI, body mass index; if-mitochondria, intramyofibrillar mitochondria; IMCL, intramyocellular lipids; Pmax, maximal aerobic power output; ss-mitochondria, subsarcolemmal mitochondria; VO2max, maximal oxygen uptake; % refers to volume densities per fiber volume. Differences which passed a Bonferroni post hoc test at a p-value of < 0.05, and the name of the corresponding parameter, appear in bold, underlined font.