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Skin temperature (°C) (A) and blood flow (flux) (B) between the five groups at before (day 0) and during 4 days experiment without or with LPS injection via therapeutic ultrasound treatment with niosome placebo, nioplai or neurofen. Each point presents the mean and standard error of mean from each of five rats. *P<0.01 compared to the control group on each day, and #P<0.01 when compared to the LPS group on each day.
Abbreviation: LPS, lipopolysaccharide.
