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. 2017 Mar 31;12:2531–2551. doi: 10.2147/IJN.S129274

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© 2017 Ke et al. This work is published and licensed by Dove Medical Press Limited

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Schematic representation of the putative mechanism by which AuNPs potentiate the response of NSCLC cells to TRAIL.

Notes: TRAIL combined with AuNPs promotes apoptotic response by Drp1-mediated mitochondrial fragmentation. Excessive mitochondrial fragmentation might trigger an autophagic response. Apoptosis and autophagy are two synergic cellular mechanisms, which lead to enhanced TRAIL sensitivity mediated by AuNPs in NSCLC cells.

Abbreviations: AuNPs, gold nanoparticles; Drp1, dynamin-related protein 1; NSCLC, non-small-cell lung cancer; TRAIL, tumor necrosis factor-related apoptosis-inducing ligand.