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. 2017 Mar 31;12:2607–2620. doi: 10.2147/IJN.S133078

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© 2017 Cho et al. This work is published and licensed by Dove Medical Press Limited

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Scheme 1 — Schematic illustrations of the fabrication and photothermal-modulating strategy of injectable collagen/γ-PGA/Dox/ICG/MnFe₂O₄ hydrogels.

Notes: Collagen/γ-PGA hydrogels containing MnFe₂O₄, Dox, and ICG (collagen/γ-PGA/Dox/ICG/MnFe₂O₄ hydrogels) were fabricated by mixing collagen solution and γ-PGA solution containing γ-PGA-coated MnFe₂O₄, Dox, and ICG. Collagen/γ-PGA/Dox/ICG/MnFe₂O₄ complexes were easy to inject using a syringe and formed hydrogels after injection into the body. Following hydrogel formation, collagen/γ-PGA/Dox/ICG/MnFe₂O₄ hydrogels were disrupted after irradiation with an NIR laser. This resulted in the release of Dox, ICG, and MnFe₂O₄ from the hydrogels.

Abbreviations: γ-PGA, poly(γ-glutamic acid); Dox, doxorubicin; ICG, indocyanine green; NIR, near-infrared; PBS, phosphate-buffered saline; T, temperature.