Fig. 6.
In vivo optical bioluminescence imaging (BLI) showed greater retention and survival for encapsulated HEK-293 (Luc-2) cells compared to those of direct injection. (A) BLI image of representative animal from each group (n=5), showing increased cell retention in the animal administered encapsulated cells at day 7. (B) Quantification of BLI signal in regions of interest in the subcutaneous tissue at the total flux level of 108 p/s at 0 hr, 1 day and 3 days showed no significant difference between the groups. (C) Quantification of BLI signal in regions of interest in the subcutaneous tissue at the total flux level of 106 p/s showed significantly greater signal in the animals treated with encapsulated cells at day 7.