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. Author manuscript; available in PMC: 2018 Mar 16.
Published in final edited form as: Neurosci Lett. 2017 Feb 14;643:65–69. doi: 10.1016/j.neulet.2017.02.031

Figure 3. Toxicity of 3-NP is more severe in L-12/15 LO null mutant mice.

Figure 3

(A) The number of L-12/15 LO +/+ and −/− mice determined to be moribund are expressed as the percent of the total number of mice subjected to the systemic injection paradigm (fraction within bars). Moribund is defined as any mouse found dead (number shown in parentheses within the bars) or mice sacrificed due to excessive weight lost (>20%) or severe motor behavioral deficits (score ≥ 9). (*) significantly different from +/+ group (p = 0.039, Chi-squared test). (B) A Kaplan–Meier survival curve depicts the rate at which the mice were removed from study. The shaded region represents the 9-day dosing paradigm. No genotypic differences in rate of removal was determined by Mantel-COX log-rank test.