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. Author manuscript; available in PMC: 2018 Apr 1.
Published in final edited form as: Cell Immunol. 2017 Feb 21;314:54–62. doi: 10.1016/j.cellimm.2017.02.002

Figure 4. Regulation of the PerC B cell response to BCR ligation by exogenous cytokines or prostaglandin.

Figure 4

Figure 4

C57BL/6J PerC cells were cultured with αCD3 or αIgM +/− the inducible nitric oxide synthase (iNOS) inhibitor NG-monomethyl_L-arginine (1-MA), the indoleamine 2,3 dioxygenase inhibitor (IDO) 1 methyl-tryptophan (1-MT), the arginase (ARG) inhibitor N-ω-hydroxy-nor L arginine (1-NA), the cyclooxygenase (COX) inhibitor indomethacin (INDO), αIFNγ, αIL-10, and/or αIL-4 (A). The exogenous cytokines IL-4, IL-10, or IL-13 +/− indomethacin were added to C57BL/6J PerC cells cultured with αIgM (B). C57BL/6J and BALB/c PerC cells were cultured with αIgM and exogenous cytokines (C).