. 2017 Apr 6;12(4):e0175071. doi: 10.1371/journal.pone.0175071

Table 2. Interactions with physical activity.

Trait	SNP	Age group	Gender	β_PA	β_SNP	β_SNP*PA	95% CI for β_SNP*PA	Adjusted p-value
WHR	FTO	20–40 years	Men	-0.0026	0.017	-0.0029	-0.0048, -0.0011	0.029
		20–40 years	Women	6.9e-05	0.017	-0.0028	-0.0048, -0.00073	0.048
		40–60 years	Men	-0.0066	0.0024	0.00028	-0.001, 0.0016	0.86
		40–60 years	Women	-0.0038	0.0018	0.00034	-0.0012, 0.0019	0.86
		60–80 years	Men	-0.007	0.0044	-0.00051	-0.0023, 0.0013	0.81
		60–80 years	Women	-0.0088	-0.00081	0.00064	-0.0017, 0.003	0.86
	MC4R	20–40 years	Men	-0.0026	0.0085	-0.0013	-0.0034, 0.00071	0.51
		20–40 years	Women	6.9e-05	0.01	-0.001	-0.0032, 0.0012	0.7
		40–60 years	Men	-0.0066	0.0042	-0.00043	-0.0019, 0.0011	0.84
		40–60 years	Women	-0.0038	0.0051	-0.00043	-0.0022, 0.0013	0.86
		60–80 years	Men	-0.007	-0.0066	0.0016	-0.00033, 0.0036	0.3
		60–80 years	Women	-0.0088	0.0068	-0.00014	-0.0027, 0.0025	1
BMI	FTO	20–40 years	Men	-0.041	1.0	-0.15	-0.28, -0.018	0.11
		20–40 years	Women	0.053	1.4	-0.2	-0.34, -0.049	0.048
		40–60 years	Men	-0.22	0.36	-0.0088	-0.1, 0.082	1
		40–60 years	Women	-0.30	0.84	-0.078	-0.2, 0.04	0.45
		60–80 years	Men	-0.40	-0.078	0.075	-0.043, 0.19	0.46
		60–80 years	Women	-0.66	0.14	0.027	-0.14, 0.19	0.95
	MC4R	20–40 years	Men	-0.041	0.26	-0.0075	-0.15, 0.14	1
		20–40 years	Women	0.053	1.7	-0.24	-0.41, -0.078	0.025
		40–60 years	Men	-0.22	0.46	-0.031	-0.13, 0.073	0.81
		40–60 years	Women	-0.3	0.024	0.048	-0.085, 0.18	0.78
		60–80 years	Men	-0.4	-0.6	0.14	0.015, 0.27	0.11
		60–80 years	Women	-0.66	0.64	-0.046	-0.23, 0.14	0.86

Gene-environment interaction effects for physical activity (PA); estimated main effect of physical activity (β_PA), estimated main effect of SNPs (β_SNP), estimated GEI effects (β_SNP*PA), 95% confidence intervals for the GEI effects and FDR-adjusted p-value for testing H₀: β_SNP*PA = 0 against H₀: β_SNP*PA ≠ 0.