Table 3. Interactions with artificially sweetened beverages.

Trait	SNP	Age group	Gender	βASB	βSNP	βSNP*ASB	95% CI for βSNP*ASB	Adjusted p-value
WHR	FTO	20–40 years	Men	0.0013	0.0029	0.00037	-0.00018, 0.00091	0.43
			Women	0.0013	0.005	-4.3e-05	-0.00056, 0.00047	1
		40–60 years	Men	0.0011	0.0024	0.00043	-6.1e-05, 0.00093	0.43
			Women	0.0012	0.0025	3e-04	-2e-04, 0.00081	0.66
		60–80 years	Men	8e-04	0.00059	0.00094	6.3e-05, 0.0018	0.15
			Women	0.0015	0.0013	0.00032	-0.00067, 0.0013	0.87
	MC4R	20–40 years	Men	0.0013	0.0046	-0.00041	-0.001, 0.00019	0.43
			Women	0.0013	0.0051	0.00013	-0.00043, 7e-04	0.89
		40–60 years	Men	0.0011	0.0028	-0.00016	-0.00072, 0.00039	0.72
			Women	0.0012	0.0026	0.00027	-3e-04, 0.00084	0.72
		60–80 years	Men	8e-04	0.0017	-7e-04	-0.0016, 0.00018	0.19
			Women	0.0015	0.0068	-0.00042	-0.0015, 7e-04	0.72
BMI	FTO	20–40 years	Men	0.085	0.13	0.059	0.021, 0.097	0.024
			Women	0.14	0.52	0.002	-0.037, 0.041	1
		40–60 years	Men	0.056	0.19	0.053	0.019, 0.086	0.024
			Women	0.17	0.46	0.013	-0.025, 0.052	0.81
		60–80 years	Men	0.074	0.15	0.059	-0.00049, 0.12	0.15
			Women	0.19	0.35	-0.069	-0.14, 0.0046	0.2
	MC4R	20–40 years	Men	0.085	0.39	-0.038	-0.082, 0.0049	0.22
			Women	0.14	0.62	0.0028	-0.041, 0.046	1
		40–60 years	Men	0.056	0.33	-0.00019	-0.039, 0.039	1
			Women	0.17	0.3	-0.024	-0.067, 0.02	0.59
		60–80 years	Men	0.074	0.044	-0.021	-0.08, 0.038	0.62
			Women	0.19	0.41	0.025	-0.064, 0.11	0.78

Gene-environment interaction effects for artificially sweetened beverages (ASB; estimated main effect of artificially sweetened beverages (β_ASB), estimated main effect of SNPs (β_SNP), estimated GEI effects (β_SNP*ASB), 95% confidence intervals for the GEI effects and FDR-adjusted p-value for testing H₀: β_SNP*ASB = 0 against H₁: β_SNP*ASB ≠ 0.