. 2017 Apr 6;12(4):e0175071. doi: 10.1371/journal.pone.0175071

Table 4. Interactions with pack years.

Trait	SNP	Age group	Gender	β_PCYR	β_SNP	β_SNP*PCYR	95% CI for β_SNP*PCYR	Adjusted p-value
WHR	FTO	20–40 years	Men	0.001	0.0044	2e-05	-0.00071, 0.00075	1
		20–40 years	Women	0.0016	0.0039	0.00042	-0.00036, 0.0012	0.59
		40–60 years	Men	0.00045	0.0013	3e-04	0.00011, 0.00048	0.81
		40–60 years	Women	0.00079	0.0018	0.00023	-8.8e-06, 0.00046	1
		60–80 years	Men	0.00036	-3.2e-5	0.00019	1.7e-05, 0.00036	1
		60–80 years	Women	-0.00011	-0.0015	0.00036	7.3e-05, 0.00065	0.73
	MC4R	20–40 years	Men	0.001	0.0017	5e-04	-0.00035, 0.0013	0.5
		20–40 years	Women	0.0016	0.0057	-3.3e-06	-0.00078, 0.00077	1
		40–60 years	Men	0.00045	0.0022	1.8e-05	-0.00019, 0.00023	1
		40–60 years	Women	0.00079	0.0042	-0.00013	-0.00039, 0.00013	0.42
		60–80 years	Men	0.00036	-0.0015	0.00014	-2.9e-05, 0.00031	1
		60–80 years	Women	-0.00011	0.0063	-7e-05	-0.00039, 0.00025	1
BMI	FTO	20–40 years	Men	0.076	0.37	0.00098	-0.051, 0.053	1
		20–40 years	Women	0.018	0.4	0.063	0.0056, 0.12	0.1
		40–60 years	Men	0.0012	0.2	0.016	0.0041, 0.028	0.048
		40–60 years	Women	0.033	0.63	-0.019	-0.036, -0.0023	0.1
		60–80 years	Men	0.023	0.31	-0.0053	-0.016, 0.0055	0.73
		60–80 years	Women	-0.036	0.11	0.02	0.0015, 0.039	0.11
	MC4R	20–40 years	Men	0.076	0.24	-0.0045	-0.066, 0.057	1
		20–40 years	Women	0.018	0.56	0.026	-0.03, 0.083	0.5
		40–60 years	Men	0.0012	0.34	-0.0014	-0.015, 0.012	1
		40–60 years	Women	0.033	0.37	-0.018	-0.037, 0.00021	0.15
		60–80 years	Men	0.023	0.099	-0.0078	-0.018, 0.0026	0.42
		60–80 years	Women	-0.036	0.54	-0.011	-0.033, 0.011	0.5

Gene-environment interaction effects for pack-years (PCYR); estimated main effect of smoking (β_PCYR), estimated main effect of SNPs (β_SNP) and estimated GEI effects (β_SNP*PCYR), 95% confidence intervals for the GEI effects and FDR-adjusted p-value for testing H₀: β_SNP*PCYR = 0 against H₁: β_SNP*PCYR ≠ 0.