Table 1. Demographic characteristics, source of isolates and focus of infection of the study population.

		pre-PCV13 (2008–2009)		PCV13 (2012–2013)		p*
Demographics	Age mean (years)	59.5		64.7		<0.001
	Male (%)	60.0		58.5		0.56
Source of isolates		Episodes(n)	%	Episodes(n)	%
	Blood culture	822	86.6	520	85.4	0.43
	Cerebrospinal fluid	47	5.0	41	6.7	0.14
	Pleural fluid	54	5.7	28	4.6	0.35
	Ascitic fluid	15	1.6	13	2.1	0.42
	Other	11	1.2	7	1.1	0.99
Focus of infection		Episodes(n)	Incidence**	Episodes(n)	Incidence**
	Pneumonia	700	9.03	451	6.00	<0.001
	Meningitis	80	1.03	66	0.87	0.33
	Peritonitis	33	0.43	23	0.31	0.22
	Unknown focus	102	1.31	48	0.64	<0.001
	Other	34	0.44	21	0.28	0.10

* p-value comparing pre-PCV13 and PCV13 periods

** Number of episodes per 100.000 population.