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. 2017 Apr 6;12(4):e0175247. doi: 10.1371/journal.pone.0175247

Table 6. Detailed results for repeatability (DA), reproducibility (CO) and concordance odds ratio (COR) obtained during the collaborative study for the different methods.

Sample codes Criteria Results obtained for each method
M1 M2 Maa M3 M4 M5 M6
A1 DAb 0.94 1.00 0.94 0.94 0.90 1.00 1.00
COc 0.68 0.40 0.20 0.68 0.76 1.00 1.00
CORdf 7.37 inf 62.67 7.37 2.84 1.00 1.00
CICORef 2.92–18.61 - 9.19–427.28 2.92–18.61 1.28–6.32 - -
Pfg 0.002 S** 0.000 S*** 0.048 S* 0.002 S** 0.022 S* 1.000 NS 1.000 NS
A2 DA 0.90 1.00 0.94 0.90 0.94 1.00 1.00
CO 0.84 0.40 0.80 0.84 0.92 1.00 1.00
COR 1.71 inf 3.92 1.71 1.36 1.00 1.00
CICOR 0.74–3.99 - 0.57–26.71 0.74–3.99 0.45–4.08 - -
p 0.167 NS 0.000 S*** 1.000 NS 0.167 NS 1.000 NS 1.000 NS 1.000 NS
A3 DA 0.94 0.90 0.94 0.94 1.00 1.00 1.00
CO 0.92 0.52 0.80 0.92 1.00 1.00 1.00
COR 1.36 8.31 3.92 1.36 1.00 1.00 1.00
CICOR 0.45–4.08 3.88–17.80 0.57–26.71 0.45–4.08 -! - -
p 1.000 NS 0.000 S*** 1.000 NS 1.000 NS 1.000 NS 1.000 NS 1.000 NS
A4 DA 0.65 0.84 0.87 0.94 0.90 1.00 0.94
CO 0.51 0.70 0.68 0.68 0.84 1.00 0.92
COR 1.78 2.25 3.15 7.37 1.71 1.00 1.36
CICOR 1.01–3.15 1.13–4.46 0.75–13.25 2.92–18.61 0.74–3.99 - 0.45–4.08
p 0.290 NS 0.081 NS 1.000 NS 0.002 S** 0.167 NS 1.000 NS 1.000 NS
A5 DA 0.68 1.00 0.90 0.90 1.00 1.00 0.78
CO 0.58 1.00 0.60 0.76 1.00 1.00 0.72
COR 1.54 1.00 6.00 2.84 1.00 1.00 1.38
CICOR 0.86–2.74 - 1.30–27.77 1.28–6.32 - - 2.62
p 0.467 NS 1.000 NS 0.444 NS 0.022 S* 1.000 NS 1.000 NS 0.753 NS
B1 DA 0.90 0.94 0.94 0.94 0.81 1.00 1.00
CO 0.84 0.40 0.80 0.92 0.65 1.00 1.00
COR 1.71 23.50 3.92 1.36 2.30 1.00 1.00
CICOR 0.74–3.99 9.39–58.80 0.57–26.71 0.45–4.08 1.20–4.38 - -
p 0.167 NS 0.000 S*** 1.000 NS 1.000 NS 0.047 S* 1.000 NS 1.000 NS
B2 DA 0.94 0.94 0.87 0.84 1.00 1.00 0.90
CO 0.92 0.44 0.68 0.78 1.00 1.00 0.84
COR 1.36 19.94 3.15 1.48 1.00 1.00 1.71
CICOR 0.45–4.08 7.99–49.78 0.75–13.25 0.73–3.02 - - 0.74–3.99
p 1.000 NS 0.000 S*** 1.000 NS 0.457 NS 1.000 NS 1.000 NS 0.167 NS
B3 DA 0.58 0.90 0.90 0.90 0.87 0.90 0.68
CO 0.48 0.48 0.40 0.76 0.85 0.84 0.58
COR 1.50 9.75 13.50 2.84 1.18 1.71 1.54
CICOR 0.86–2.61 4.55–20.89 2.92–62.48 1.28–6.32 0.53–2.63 0.74–3.99 0.86–2.74
p 0.567 NS 0.000 S*** 0.167 NS 0.022 S* 1.000 NS 0.167 NS 0.467 NS
B4 DA 0.87 0.84 0.87 0.87 0.62 0.68 0.52
CO 0.85 0.58 0.32 0.85 0.48 0.62 0.50
COR 1.18 3.80 14.22 1.18 1.77 1.30 1.08
CICOR 0.53–2.63 1.95–7.40 3.38–59.84 0.53–2.63 1.01–3.10 0.73–2.33 0.62–1.89
p 1.000 NS 0.006 S** 0.206 NS 1.000 NS 0.383 NS 0.824 NS 1.000 NS
B5 DA 0.62 0.90 0.94 0.55 0.71 0.65 0.58
CO 0.55 0.76 0.20 0.50 0.57 0.49 0.56
COR 1.33 2.84 62.67 1.22 1.85 1.93 1.09
CICOR 0.76–2.35 1.28–6.32 9.19–427.28 0.70–2.13 1.03–3.32 1.10–3.41 0.62–1.90
p 0.769 NS 0.022 S* 0.048 S* 0.888 NS 0.155 NS 0.189 NS 1.000 NS
C1 DA 0.90 0.84 0.90 0.90 1.00 1.00 1.00
CO 0.84 0.50 0.60 0.40 0.60 1.00 1.00
COR 1.71 5.25 6.00 13.50 inf 1.00 1.00
CICOR 0.74–3.99 2.71–10.19 1.30–27.77 6.28–29.04 - - -
p 0.167 NS 0.003 S** 0.444 NS 0.000 S*** 0.000 S*** 1.000 NS 1.000 NS
C2 DA 0.81 1.00 0.94 0.94 1.00 1.00 0.94
CO 0.71 0.40 0.80 0.68 1.00 1.00 0.92
COR 1.74 inf 3.92 7.37 1.00 1.00 1.36
CICOR 0.90–3.37 - 0.57–26.71 2.92–18.61 - - 0.45–4.08
p 0.160 NS 0.000 S*** 1.000 NS 0.002 S** 1.000 NS 1.000 NS 1.000 NS
C3 DA 0.81 1.00 0.90 0.94 0.94 1.00 1.00
CO 0.65 0.40 0.60 0.92 0.92 1.00 1.00
COR 2.30 inf 6.00 1.36 1.36 1.00 1.00
CICOR 1.20–4.38 - 1.30–27.77 0.45–4.08 0.45–4.08 - -
p 0.047 S* 0.000 S*** 0.444 NS 1.000 NS 1.000 NS 1.000 NS 1.000 NS
C4 DA 0.81 1.00 0.90 0.81 1.00 1.00 1.00
CO 0.65 0.40 0.60 0.71 1.00 1.00 1.00
COR 2.30 inf 6.00 1.74 1.00 1.00 1.00
CICOR 1.20–4.38 - 1.30–27.77 0.90–3.37 - - -
p 0.047 S* 0.000 S*** 0.444 NS 0.160 NS 1.000 NS 1.000 NS 1.000 NS
C5 DA 0.90 0.78 0.90 0.90 0.90 1.00 0.94
CO 0.76 0.43 0.60 0.48 0.84 1.00 0.92
COR 0.76 0.43 0.60 0.48 0.84 1.00 0.92
CICOR 1.28–6.32 2.54–8.71 1.30–27.77 4.55–20.89 0.74–3.99 - 0.45–4.08
p 0.022 S* 0.007 S** 0.444 S* 0.000 S*** 0.167 NS 1.000 NS 1.000 NS

aValues for method Ma were calculated from the results of 2 laboratories (vs 5 for other methods).

bRepeatability: is the probability of finding the same result from two identical test portions analyzed in the same laboratory, under repeatability conditions

cReproducibility: is the percentage chance of finding the same result for two identical samples analyzed in two different laboratories

dThe concordance odds ratio was calculated as the ratio DA x (1—CO)/CO x (1- DA). The larger the odds ratio (above 1), the more predominant the interlaboratory variation

eConfidence interval (95%) of the concordance odds ratio calculated with Woolf’s logit method

fThe shaded cells indicate statistical significance of variation between laboratories.

gp-value of Fisher’s exact test used to evaluate the statistical significance of the variation between laboratories: NS: not significant (p ≥ 0.05); S*: 0.01≤ p < 0.05; S**: 0.001 ≤ p < 0.01; S***: p < 0.001