Table 6. Pharmacological Impacts on 50-kHz Vocalizations.
| Effect | Drugs | Author year |
|---|---|---|
| Increase | Buspirone or SSR181507 after Phencyclidine application | Boulay 2013 |
| Metyrapone + Stress (compared to Vehicle + Stress) | Popik 2014 | |
| Naloxone for socially housed rats | Burgdorf 2001 | |
| Amphetamine | Koiv 2016; | |
| Decrease | Phencyclidine | Boulay 2013 |
| Naloxone for individually housed rats | Burgdorf 2001 | |
| MK-801 | Panksepp 2000 | |
| SCH23390 or Racolpride | Hori 2013 | |
| No effect | Quipazine, Cyprohetadine, Morphine, Scopolamine, Amphetamine, or Haloperidol | Panksepp 2000 |
| Aripiprazole, Eplivanzerin, SSR103800, SSR181507, Diazepam, Buspirone, or Fluoxetine | Boulay 2013 | |
| Aripiprazole, Eplivanzerin, SSR103800, Diazepam, or Fluoxetine after Phencyclidine application | Boulay 2013 |
A summary of the impact of various drugs on the production of positive 50-kHz vocalizations produced by rats during tickling. Italics indicate drugs in which mixed results have been found.