Fig 3. Representative experiment of NPS reducing 15% EtOH-induced increases in intraduodenal pressure (motility).

All rats were pretreated with i.v. parecoxib 10 mg/kg approximately 60 min before the experiment started to reverse surgery-induced paralytic ileus. A) Saline perfusion with migrating motor complex (MMC) pattern. B) Luminal 15% EtOH increased motility. C) Continuous i.v. infusion of NPS reduced basal motility (time 0–30 min) and the motility effect of 15% EtOH. D) NPS at 10× concentration further decreased basal motility (time 0–30 min) and further dampened the effect of 15% EtOH.