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. 2017 Apr 6;12(4):e0175312. doi: 10.1371/journal.pone.0175312

Fig 4. Co-administration of luminal hydrochloric acid 1.0 mM (pH 3) with intravenous NPS increases duodenal bicarbonate secretion and mucosal paracellular permeability in a NO-activity-dependent manner.

Fig 4

A) Luminal HCl pH 3 alone had no effect, but co-administration with NPS continuous i.v. infusion 83 pmol·kg-1·min-1 significantly increased duodenal bicarbonate secretion and B) inhibited the duodenal mucosal paracellular permeability reduction except in animals pretreated with L-NAME. C) No significant changes were observed in duodenal motility. D) NPS had no effect on HCl-induced net fluid absorption. Pretreatment with L-NAME stimulated net fluid secretion. # indicates a significant (P<0.05) difference compared with baseline (0–30 min) in the same group. * indicates significantly (P<0.05) higher than the other groups.