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. 2017 Apr 6;12(4):e0175467. doi: 10.1371/journal.pone.0175467

Fig 1. Intestinal correction of CFTR does not improve growth.

Fig 1

(A) Weight of CF mice, gut-corrected CF mice and control littermates was assessed up to 40 days of age (n≥10 of each sex). Weight was significantly decreased in CF and gut-corrected CF mice compared to control animals at every age measured (P<0.001) with equal numbers of each sex used. (B) Length and (C) inguinal fat weight of CF mice, gut-corrected CF mice and control littermates was assessed between 6–7 weeks of age (n≥10 of each sex). Both length and inguinal fat weight was significantly decreased in CF and gut-corrected CF mice compared to control animals independent of sex (* = P<0.05; data represent mean±SE). (D) Survival of CF and gut-corrected CF between 10–42 days of age. All deaths were the result of intestinal obstruction as verified by postmortem examination.