Fig 2. IGF-1 levels are reduced in CF and gut-corrected CF mice and correlate with growth.

(A) Igf1 expression and (B) IGF-1 serum levels are significantly reduced at 6 weeks of age in both CF and gut-corrected CF mice compared to control littermates (* = P<0.05; n≥6; data represent mean±SE). IGF-1 levels were significantly correlated with weight in (C) CF and (D) gut-corrected CF mice (P<0.05; n≥10).