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. 2017 Apr 6;12(4):e0175467. doi: 10.1371/journal.pone.0175467

Fig 3. Reduced growth in CF mice occurs prenatally in the absence of reduced IGF-1.

Fig 3

(A) A Mendelian distribution was observed in fetuses originating from Cftr heterozygote matings. (n>100) (B) Weight was significantly reduced in newborn CF mice and e18 fetuses compared to control littermates but the groups did not differ at e15. (C) IGF-1 levels were not significantly different between CF and control littermates perinatally (e18 and newborn) but IGF-1 levels were significantly reduced between CF and control littermates at 3 weeks of age. (* = P<0.05; n≥15; data represent mean±SE)