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Initiation of aggressive prostate cancer by oncogene-expressing Proliferative Inflammatory Atrophy (PIA)-like luminal cells. PIA-like luminal cells (red) are associated with regions that contain inflammation (blue). When lentivirally transduced with oncogenes (Myc, AKT1, and androgen receptor), these cells expand and can initiate aggressive prostate cancer (bottom right corner). Visualization by Kandeo Studios.
