Table 2.
Comparison of histopathologic findings at biopsy between the patients of low birth weight–FSGS, normal birth weight–FSGS, and normal birth weight–minimal change nephrotic syndrome
| Variables | All | LBW-FSGS | NBW-FSGS | P Value | NBW-MCNS | P Value |
|---|---|---|---|---|---|---|
| Cases, n | 31 | 8 | 10 | 13 | ||
| Total glomerular number | 24.5±12.3 | 15.9±10.0 | 24.5±5.4a | 0.04 | 29.7±14.9a | 0.04 |
| Total cortical area, mm2 | 8.5±3.4 | 10.1±4.3 | 7.7±2.3 | 0.24 | 8.2±3.4 | 0.24 |
| IF/TA, % | 5.6±11.2 | 11.9±14.7 | 7.5±13.0 | 0.36 | 0.4±11.4 | 0.07 |
| Global glomerular sclerosis, % | 0 (0–0) | 0 (0–1.2) | 1.85 (0–4.5) | 0.46 | 0 (0–0) | 0.37 |
| Focal segmental sclerosis, % | 2.6±5.1 | 2.3±4.4 | 6.2±7.0 | 0.15 | 0 | 0.37 |
| GV (× 106 μm3) | 1.8 (1.4–2.6) | 4.0 (3.0–5.1) | 1.6 (1.5–2.1)a | <0.001 | 1.3 (1.1–1.8)a | <0.001 |
| GD excluding globally sclerotic glomeruli, /mm2 | 3.0±1.4 | 1.4±0.6 | 3.3±1.2a | 0.002 | 3.6±1.1a | <0.001 |
| GD including globally sclerotic glomeruli, /mm2 | 3.0±1.3 | 1.4±0.6 | 3.4±1.1a | 0.001 | 3.6±1.1a | <0.001 |
LBW-FSGS, low birth weight–FSGS; NBW-FSGS, normal birth weight–FSGS; NBW-MCNS, normal birth weight–minimal change nephrotic syndrome; IF/TA, interstitial fibrosis/tubular atrophy; GV, glomerular volume; GD, glomerular density. Data are expressed as mean±SD or median with interquartile range (25th–75th percentile).
a
P<0.05 versus LBW-FSGS.