Table 2.
Association of serum triglyceride/HDL cholesterol ratio with all-cause mortality, stratified by decile categories
| TG/HDL-C Levels | Unadjusted | Case-Mix | Case-Mix and MICS | Case-Mix, MICS, and Statin | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | P Value | HR | 95% CI | P Value | HR | 95% CI | P Value | HR | 95% CI | P Value | |
| Baseline model | ||||||||||||
| <1.59 | 1.02 | (0.95 to 1.10) | 0.55 | 1.06 | (0.98 to 1.14) | 0.15 | 1.04 | (0.97 to 1.13) | 0.29 | 0.99 | (0.91 to 1.08) | 0.89 |
| 1.59 to <2.09 | 1.03 | (0.95 to 1.11) | 0.46 | 1.02 | (0.95 to 1.10) | 0.59 | 1.00 | (0.93 to 1.08) | 0.99 | 0.96 | (0.89 to 1.05) | 0.38 |
| 2.09 to <2.57 | 1.07 | (0.99 to 1.16) | 0.07 | 1.04 | (0.96 to 1.12) | 0.34 | 1.02 | (0.94 to 1.10) | 0.67 | 0.98 | (0.90 to 1.07) | 0.70 |
| 2.57 to <3.07 | 1.03 | (0.96 to 1.11) | 0.41 | 1.01 | (0.94 to 1.09) | 0.78 | 1.00 | (0.92 to 1.08) | 0.99 | 0.98 | (0.90 to 1.07) | 0.67 |
| 3.07 to <3.64 | 1.01 | (0.93 to 1.09) | 0.85 | 0.97 | (0.89 to 1.04) | 0.37 | 0.94 | (0.87 to 1.02) | 0.14 | 0.95 | (0.87 to 1.03) | 0.20 |
| 3.64 to <4.30 | 1.00 | 1.00 | 1.00 | 1.00 | ||||||||
| 4.30 to <5.18 | 0.96 | (0.88 to 1.03) | 0.26 | 0.94 | (0.87 to 1.01) | 0.10 | 0.96 | (0.89 to 1.04) | 0.35 | 0.97 | (0.89 to 1.05) | 0.43 |
| 5.18 to <6.41 | 0.92 | (0.85 to 1.00) | 0.04 | 0.92 | (0.85 to 0.99) | 0.03 | 0.95 | (0.88 to 1.03) | 0.21 | 0.93 | (0.86 to 1.02) | 0.12 |
| 6.41 to <8.63 | 0.89 | (0.82 to 0.96) | 0.004 | 0.90 | (0.83 to 0.97) | 0.01 | 0.93 | (0.86 to 1.01) | 0.07 | 0.92 | (0.84 to 1.00) | 0.05 |
| ≥8.63 | 0.79 | (0.73 to 0.86) | <0.001 | 0.85 | (0.78 to 0.92) | <0.001 | 0.91 | (0.83 to 0.99) | 0.03 | 0.90 | (0.82 to 0.99) | 0.02 |
| Time-varying model | ||||||||||||
| <1.38 | 1.03 | (0.96 to 1.11) | 0.43 | 1.10 | (1.02 to 1.19) | 0.001 | 1.12 | (1.04 to 1.21) | 0.004 | 1.10 | (1.01 to 1.20) | 0.03 |
| 1.38 to <1.84 | 1.07 | (1.00 to 1.16) | 0.06 | 1.10 | (1.02 to 1.19) | 0.01 | 1.09 | (1.01 to 1.18) | 0.03 | 1.09 | (1.00 to 1.18) | 0.05 |
| 1.84 to <2.28 | 1.09 | (1.01 to 1.17) | 0.03 | 1.09 | (1.01 to 1.17) | 0.03 | 1.06 | (0.99 to 1.15) | 0.12 | 1.07 | (0.98 to 1.16) | 0.12 |
| 2.28 to <2.76 | 1.08 | (1.00 to 1.17) | 0.04 | 1.07 | (1.00 to 1.16) | 0.06 | 1.03 | (0.95 to 1.11) | 0.45 | 1.04 | (0.96 to 1.13) | 0.36 |
| 2.76 to <3.32 | 1.05 | (0.97 to 1.13) | 0.20 | 1.05 | (0.97 to 1.13) | 0.21 | 1.04 | (0.96 to 1.12) | 0.37 | 1.04 | (0.96 to 1.13) | 0.32 |
| 3.32 to <4.00 | 1.00 | 1.00 | 1.00 | 1.00 | ||||||||
| 4.00 to <4.88 | 0.91 | (0.84 to 0.98) | 0.01 | 0.92 | (0.85 to 0.99) | 0.03 | 0.95 | (0.88 to 1.03) | 0.23 | 0.91 | (0.84 to 1.00) | 0.04 |
| 4.88 to <6.17 | 0.85 | (0.79 to 0.92) | <0.001 | 0.86 | (0.80 to 0.93) | <0.001 | 0.89 | (0.82 to 0.97) | 0.01 | 0.89 | (0.82 to 0.98) | 0.01 |
| 6.17 to <8.57 | 0.79 | (0.73 to 0.86) | <0.001 | 0.83 | (0.76 to 0.90) | <0.001 | 0.89 | (0.82 to 0.97) | 0.01 | 0.88 | (0.81 to 0.97) | 0.01 |
| ≥8.57 | 0.71 | (0.65 to 0.77) | <0.001 | 0.78 | (0.71 to 0.85) | <0.001 | 0.86 | (0.79 to 0.94) | 0.001 | 0.86 | (0.78 to 0.94) | 0.002 |
Adjustments in case-mix model (n=50,105): age, sex, race/ethnicity, primary insurance, vascular access type, comorbid conditions, alcohol dependence, substance abuse, and single-pool Kt/V. Adjustments in case-mix plus MICS model (n=48,527): case-mix adjusted model plus laboratory parameters including serum hemoglobin, white blood cell count, albumin, calcium, phosphorus, intact parathyroid hormone, bicarbonate, total iron binding capacity, ferritin, LDL cholesterol, and body mass index. Adjustments in case-mix plus MICS plus statin model (n=43,742): statin therapy on the fully adjusted models. TG/HDL-C, triglyceride/HDL cholesterol ratio; MICS, malnutrition-inflammation-cachexia syndrome; HR, hazard ratio; 95% CI, 95% confidence interval.