Table 3.
The association of TNFR2 and hsCRP with the annual change in mGFR and eGFR in linear mixed regression models
| Dependent Variable and Risk Factor | Model 1 Unadjusted | Model 2 Adjusted for Baseline Covariatesa | Model 3 Adjusted for Time-Dependent Covariatesa | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Estimate (ml/min per 1.73 m2 per yr) | 95% CI | P Value | Estimate (ml/min per 1.73 m2 per yr) | 95% CI | P Value | Estimate (ml/min per 1.73 m2 per yr) | 95% CI | P Value | |
| TNFR2b | |||||||||
| mGFR | 0.05 | −0.04 to 0.14 | 0.24 | 0.09 | 0.01 to 0.18 | 0.04 | 0.11 | 0.02 to 0.19 | 0.02 |
| eGFRcre | 0.03 | −0.03 to 0.09 | 0.27 | 0.04 | −0.02 to 0.10 | 0.19 | 0.04 | −0.02 to 0.99 | 0.17 |
| eGFRcys | 0.04 | −0.03 to 0.12 | 0.26 | 0.07 | −0.01 to 0.14 | 0.07 | 0.05 | −0.02 to 0.13 | 0.14 |
| eGFRcrecys | 0.08 | 0.01 to 0.14 | 0.02 | 0.09 | 0.02 to 0.16 | 0.01 | 0.08 | 0.02 to 0.15 | 0.01 |
| hsCRP | |||||||||
| mGFR | −0.03 | −0.05 to −0.02 | <0.001 | −0.03 | −0.05 to −0.01 | 0.001 | −0.03 | −0.05 to –0.01 | 0.001 |
| eGFRcre | −0.02 | −0.03 to −0.01 | <0.001 | −0.02 | −0.03 to −0.01 | <0.001 | −0.02 | −0.03 to −0.01 | 0.001 |
| eGFRcys | 0.01 | −0.01 to 0.02 | 0.46 | 0.01 | −0.01 to 0.02 | 0.27 | 0.01 | −0.01 to 0.02 | 0.32 |
| eGFRcrecys | −0.01 | −0.02 to 0.01 | 0.38 | −0.01 | −0.02 to 0.01 | 0.45 | −0.01 | −0.02 to 0.01 | 0.42 |
The Renal Iohexol-Clearance Survey Follow-Up Study. The estimates represent the interaction between time and 1 SD higher TNFR2 and 1 mg/L higher hsCRP on the annual change in mGFR/eGFR. A positive estimate represents a slower decline. Each row represents a separate linear mixed model with the different mGFR/eGFR as dependent variable. TNFR2, soluble TNF receptor 2; hsCRP, high-sensitivity C-reactive protein; mGFR, measured GFR; 95% CI, 95% confidence interval; eGFRcre, eGFR on the basis of creatinine; eGFRcys, eGFR on the basis of cystatin C; eGFRcrecys, eGFR on the basis of creatinine and cystatin C.
Adjusted for sex; weight; height; systolic BP; LDL cholesterol; HDL cholesterol; fasting triglycerides; hemoglobin A1c; urinary albumin-to-creatinine; number of cigarettes currently smoked; the use of angiotensin receptor blockers, and nonsteroidal anti-inflammatory drugs; and a dichotomous variable for the weekly use of alcohol.
The SD for TNFR2 is 651.5.