Table 4.

The association of TNFR2 and hsCRP with the risk of rapid decline in mGFR and eGFR in logistic regression models

Rapid GFR Decline	Unadjusted			Adjusted for Sex and Baseline Age, Weight, and Height			Fully Adjusteda
	Odds Ratio	95% CI	P Value	Odds Ratio	95% CI	P Value	Odds Ratio	95% CI	P Value
TNFR2b
mGFR	0.76	0.47 to 1.21	0.25	1.05	0.63 to 1.73	0.86	0.93	0.53 to 1.63	0.79
eGFRcre	1.12	0.69 to 1.93	0.59	1.13	0.67 to 1.92	0.65	1.11	0.62 to 2.00	0.72
eGFRcys	1.58	1.08 to 2.31	0.02	1.31	0.81 to 2.12	0.27	1.30	0.78 to 2.18	0.32
eGFRcrecys	1.09	0.69 to 1.71	0.72	1.06	0.63 to 1.79	0.83	1.00	0.56 to 1.78	0.99
hsCRP
mGFR	1.04	1.01 to 1.07	0.01	1.03	1.01 to 1.06	0.02	1.03	1.00 to 1.07	0.07
eGFRcre	1.05	1.02 to 1.08	0.001	1.05	1.02 to 1.08	0.001	1.05	1.02 to 1.08	0.001
eGFRcys	1.02	0.99 to 1.04	0.29	1.01	0.98 to 1.04	0.48	1.01	0.98 to 1.04	0.67
eGFRcrecys	1.00	0.98 to 1.01	0.72	1.02	0.98 to 1.05	0.32	1.01	0.98 to 1.04	0.55

The Renal Iohexol-Clearance Survey Follow-Up Study. The odds ratios represent 1 SD higher TNFR2 and 1 mg/L higher hsCRP. Each row represents separate logistic regression models with rapid decline in mGFR or eGFR (≥3.0 ml/min per 1.73 m² per year) as a dependent variable. TNFR2, soluble TNF receptor 2; hsCRP, high-sensitivity C-reactive protein; mGFR, measured GFR; 95% CI, 95% confidence interval; eGFRcre, eGFR on the basis of creatinine; eGFRcys, eGFR on the basis of cystatin C; eGFRcrecys, eGFR on the basis of creatinine and cystatin C.

^aAdjusted for sex; baseline age, weight and height; systolic BP; LDL and HDL cholesterol; fasting triglycerides; hemoglobin A_1c; urinary albumin-to-creatinine ratio; number of cigarettes currently smoked; angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, or nonsteroidal anti-inflammatory drugs; a dichotomous variable for the weekly use of alcohol; and baseline mGFR or eGFR.

^bThe SD for TNFR2 is 651.5.