Figure 3.

Comparison of levels of extracellular haem at baseline and during acute malaria between both genotypical groups. Plasma concentration of haem was quantified using a chromogenic assay in duplicate wells for each sample. Data are presented as scatter‐plots. Red line across indicates the mean, while error bars indicate standard error of the mean. Patients with the HbAS genotype had higher concentration of haem at the convalescent phase of malaria (*P = 0·010 for AA versus AS at convalescence). Patients with the HbAA genotype had higher levels during malaria infection (** P = 0·026 for AA versus AS during acute malaria). Plasma concentration of haem increased within patients with the HbAA genotype (***P = 0·002 for convalescence versus malaria in AA) while no significant change was observed in patients with the HbAS genotype, P = 0·110 (Student's t‐test). [Colour figure can be viewed at wileyonlinelibrary.com]