Table 3.

Comparison of clinical features between the semaphorin5A (Sema5A)‐positive group and Sema5A‐negative systemic lupus erythematosus (SLE) patients

	Sema5A (+) (n = 64)	Sema5A (–) (n = 88)	P‐value
Age (mean ± s.d. years)	41·79 ± 16·36	33·92 ± 12·47	0·002
Sex	60/64	79/88	0·387
Disease duration (months, median)	60 (1–480)	30 (1–360)	0·003
Fever	17/64	16/88	0·215
Rash	17/64	37/88	0·048
Raynaud's phenomenon	14/64	13/88	0·258
Alopecia	7/64	14/88	0·380
Photosensitization	4/64	14/88	0·069
Oral ulcer	2/64	7/88	0·213
Arthritis	11/64	25/88	0·108
Pleuritis	19/64	6/88	< 0·001
Lupus nephritis	37/64	25/88	< 0·001
Neuropsychological lupus	4/64	4/88	0·642
ANA (+)	61/64	85/88	0·689
dsDNA antibody (+)	40/64	55/88	1·000
SSA (+)	49/64	62/88	0·402
AnuA (+)	26/64	36/88	0·972
ACL (+)	12/64	17/88	0·930
SLEDAI	10·50 ± 7·02	8·26 ± 5·59	0·038
ESR, median, mm/h	33 (2–140)	26 (2–140)	0·269
CRP level, median mg/l	6·6 (0·1–334·7)	2 (0·1–93·1)	0·013
IgA, mean ± s.d., g/l	2·71 ± 1·75	2·71 ± 1·45	0·983
IgG, median g/l	13·61 (2·75–29·6)	16·3 (5·85–52·4)	0·023
IgM, median g/l	0·74 (0·18–2·91)	0·97 (0·95–4·91)	0·051
C3, mean ± s.d., g/l	0·52 ± 0·26	0·65 ± 0·31	0·007
C4, median, g/l	69 (20–475)	75 (15–455)	0·709
WBC, median, ×109	4·7 (1·5–14·7)	4·95 (0·4–19·8)	0·917
PLT, median, ×109	130 (10–339)	171·5 (5–196)	< 0·001

ANA = anti‐nuclear antibody; anti‐dsDNA antibody = anti‐double strand DNA antibody; ACL = anti‐cardiolipin antibody; AnuA = anti‐nucleosome antibody; SSA = anti‐SSA antibody; SLEDAI = systemic lupus erythematosus disease activity index; ESR = erythrocyte sedimentation rate; CRP = C‐reactive protein; Ig = immunoglobulin; C3 = complement component 3; C4 = complement component 4; WBC = white blood cells; PLT = platelets; s.d. = standard deviation.