Year	First Author	Design	N*	Dose Levels	MTD drug type†	Entity	Center Type
2008	Adkison	Novel	47	Various	Radiotherapy	Academic	One Center
2008	De Bono	CRM	39	7	Targeted therapy	Industry	Two Centers
2008	Grossman	CRM	12 18	Continuous	Chemotherapy	Consortium	Multicenter
2008	Guillot	CRM	31	4	Chemotherapy	Academic	Multicenter
2008	Gururangan	CRM	16 19	Continuous	Chemotherapy	Consortium	Multicenter
2008	Jimeno	CRM	21	Continuous	Targeted therapy	Academic	One Center
2008	MacDonald	CRM	31	Continuous	Targeted therapy	Consortium	Multicenter
2008	Neuenschwander	CRM	24	15	Other therapy	Industry	Multicenter
2008	Rao	CRM	17	5	Chemotherapy	Academic	One Center
2008	Saji	CRM	17	5	Chemotherapy	Academic	Multicenter
2008	Truemper	CRM	41 78	4 4	Chemotherapy	Academic	Multicenter
2009	Bailey	Novel	50	5	Targeted therapy	Industry	Multicenter
2009	Borghaei	EWOC	39 13	Continuous	Immunotherapy	Academic	Multicenter
2009	Demetri	EWOC	53	3	Targeted therapy	Industry	Multicenter
2009	Li	CRM	27	Continuous	Immunotherapy	Academic	One Center
2009	Loeb	CRM	13	Continuous	Radiotherapy	Academic	Two Centers
2010	Andre	TITE- CRM	23 10	3 4	Targeted therapy	Industry	Multicenter
2010	Fouladi	CRM	29 21	Continuous	Targeted therapy	Consortium	Multicenter
2010	Furman	TITE- CRM	18	3	Targeted therapy	Academic	Multicenter
2010	O'Donnell	CRM	14 15	4	Chemotherapy	Academic	One Center
2010	Peereboom	CRM	16 21	Continuous	Chemotherapy	Consortium	Multicenter
2010	Rathkopf	EWOC	8 8	Continuous	Targeted therapy	Industry	Multicenter
2011	Fouladi	CRM	9	2	Targeted therapy	Consortium	Multicenter
2011	Gandhi	CRM	35 12	Continuous	Targeted therapy	Industry	Multicenter
2011	Geoerger	CRM	29 21	4	Targeted therapy	Consortium	Multicenter
2011	Jakubowiak	TITE- CRM	30 20	3 4	Other therapy	Industry	Multicenter
2011	Jerusalem	TITE- CRM	40	4	Targeted therapy	Industry	Multicenter
2011	Kim	CRM	27	4	Targeted therapy	Industry	Multicenter
2011	Koolen	CRM	32 10	5 2	Chemotherapy	Industry	Multicenter
2011	Magenau	TITE- CRM	46	3	Chemotherapy	Academic	One Center
2011	Mehnert	CRM	16	Continuous	Targeted therapy	Academic	One Center
2011	Satoh	CRM	20 21	3 4	Chemotherapy	Academic	Multicenter
2011	Smith	CRM	32	Continuous	Targeted therapy	Academic	One Center
2011	Terakura	CRM	17	Continuous	Chemotherapy	Academic	Multicenter
2011	Vansteenkist	TITE- CRM	24 19	3 3	Targeted therapy	Industry	Multicenter
2011	Warren	CRM	38	Continuous	Other therapy	Consortium	Multicenter
2011	Di Stasi	CRM	5	3	Immunotherapy	Academic	One Center
2012	Ben-Josef	TITE- CRM	50	6	Radiotherapy	Academic	Two Centers
2012	Bendell	EWOC	30	Continuous	Targeted therapy	Industry	Multi center
2012	Crew	TITE- CRM	30	3	Other therapy	Academic	Multicenter
2012	Farid	CRM	18	6	Chemotherapy	Government	One Center
2012	Feng	TITE- CRM	23	11	Other therapy	Academic	One Center
2012	Geletneky	CRM	18	3	Immunotherapy	Academic	One Center
2012	Jakubowiak	TITE- CRM	35	3	Targeted therapy	Academic	Multicenter
2012	Jones	Novel	21	12	Targeted therapy	Academic	One Center
2012	Kawahara	CRM	18	3	Chemotherapy	Consortium	Multicenter
2012	Lu	CRM	31	Continuous	Targeted therapy	Academic	One Center
2012	Markman	EWOC	57	Continuous	Targeted therapy	Industry	Multicenter
2012	Mazard	CRM	17 11	5 7	Chemotherapy	Academic	One Center
2012	Moulder	CRM	15	4	Targeted therapy	Academic	One Center
2012	Reardon	EWOC	16	Continuous	Targeted therapy	Industry	Multicenter
2012	Roberts	CRM	15 14	Continuous	Targeted therapy	Industry	Multicenter
2012	Schneider	TITE- CRM	12	7	Targeted therapy	Academic	Multicenter
2012	Sinha	EWOC	19	6	Targeted therapy	Academic	One Center
2012	Tevaarwerk	TITE- CRM	24	Continuous	Other therapy	Academic	One Center
2012	Tsien	TITE- CRM	38	5	Radiotherapy	Academic	One Center
2012	Foster	Novel	20	5	Targeted therapy	Academic	Multicenter
2013	Angevin	EWOC	19	Continuous	Targeted therapy	Industry	Multicenter
2013	Cannon	Novel	79	Various	Radiotherapy	Academic	One Center
2013	Chiappella	CRM	21	4	Other therapy	Academic	Multicenter
2013	DeAngelo	EWOC	39 23 28 20	Continuous	Targeted therapy	Industry	Multicenter
2013	Finn	EWOC	25	Continuous	Targeted therapy	Industry	Multicenter
2013	Harvey	EWOC	30	Continuous	Targeted therapy	Academic	One Center
2013	Larocca	CRM	24	4	Other therapy	Academic	Multicenter
2013	Mangiacavalli	CRM	24	2	Chemotherapy	Academic	One center
2013	Schott	TITE- CRM	30	4	Targeted therapy	Academic	Multicenter
2013	Sessa	EWOC	101	Continuous	Targeted therapy	Industry	Multicenter
2013	Sharma	EWOC	22 6 19 8	5 5 3 2	Targeted therapy	Industry	Multicenter
2013	Thornton	CRM	15	5	Targeted therapy	Industry	One Center
2013	Cruz	CRM	8	3	Immunotherapy	Academic	One Center
2014	Besse	TITE- CRM	22 18	4 4	Targeted therapy	Industry	Multicenter
2014	Das	CRM	18	4	Chemotherapy	Academic	One Center
2014	Fanale	EWOC	111	Continuous	Targeted therapy	Industry	Multicenter
2014	Gandhi	Novel	60	16	Targeted therapy	Industry	Multicenter
2014	Brennan	EWOC	16	7	Chemotherapy	Industry	One Center
2014	Isakoff	Novel	32	9	Targeted therapy	Industry	Multicenter
2014	Brana	Novel	47	4 2	Targeted therapy	Industry	Multicenter
2014	Iyer	EWOC	26	4	Targeted therapy	Industry	Multicenter
2014	Tsimberidou	Novel	27	3	Chemotherapy	Industry	One Center
2014	Infante	EWOC	53	Continuous	Targeted therapy	Industry	Multicenter
2014	Doi	EWOC	31	7	Targeted therapy	Industry	Multicenter
2014	Rodon	EWOC	83	7	Targeted therapy	Industry	Multicenter
2014	Boulin	CRM	21	5	Chemotherapy	Academic	One Center
2014	Faderl	CRM	30 20	4	Chemotherapy	Academic	One Center
2014	Rodon	EWOC	73 30	7 3	Targeted therapy	Academic	Multicenter
2014	Saura	EWOC	17	2	Targeted therapy	Industry	Multicenter
2014	Shaw	EWOC	130	6	Targeted therapy	Industry	Multicenter
2014	Ando	EWOC	15	3	Targeted therapy	Industry	One Center
2014	Khouri	CRM	56	4	Chemotherapy	Academic	One Center
2014	Kobayashi	CRM	18 15	6 4	Chemotherapy	Industry	Multicenter
2014	Popovtzer	CRM	25	5	Chemotherapy	Academic	One Center
2014	Sharma	EWOC	40 33	7 6	Targeted	Industry	Multicenter

Abbreviation: CRM, Continual Reassessment Method; EWOC; Escalation with Overdose Control

^*Evaluable N, Multiple rows indicate trials with multiple arms

^†MTD drug type ‘Other’ category includes one unspecified agent