Table 1. Recent (published in 2013 or later) epidemiological findings of blood pressure's association with cardiovascular disease in the older individuals.
Study name, year published | Singapore Chinese Health Study, 20168) | Costa Rican CRELES study, 201610) | Northern Manhattan Study (US), 20169) | Taipei City Geriatric Health Examination Database, 201511) | Strobe-Compliant Study (China), 201512) | Kangwha cohort study (Korea), 201513) | REGARDS study (US), 201414) | TGLS Study (Iran), 201415) | LSUHLS (US), 201316) |
---|---|---|---|---|---|---|---|---|---|
Baseline year | 1993–1998 | 2004–2006 | 1993–2001 | 2006 | 2004–2006 | 1985 | 2003–2007 | 1999–2001 | 1999–2009 |
Follow-up, years | max: 10 | mean: 5.1 | median: 13 | max: 4 | median: 4.8 | max: 23.8 | median: 4.5 | median: 10 | mean: 6.0 |
Age range or mean age, years | 48–85, 63.0 ± 7.8 | 60-, 76 ± 10.2 | 60-, 72 ± 8 | 65-, 73.0 | 60-, 69.5 ± 7.0 | 55-, 66.7 ± 8.0 | 55-, 79.3 ± 3.7 [for those aged ≥ 75] | 60-, 65.8 | 30–94 |
Sample size | 30,692 (n of age ≥ 60 = 19,110) | 2,346 | 1,750 | 77,389 | 5,006 | 6,294 (n of age ≥ 65 = 3,387) | 9,787 (n of age ≥ 75 = 1,839) | 1,845 | 30,154 |
Inclusion criteria related to histories | none | those without stroke, heart disease or cancer | those without stroke, DM, and CKD | none | those with HT | those taking antihypertensive medications | those without CVD | DM patients without a history of CHD or stroke | |
Women (%) | 55.7% | 57.2% | 63.0% | 49.2% | 51.4% | 57.2% | 63.1% [for those aged ≥ 75] | 49.6% | 64% |
Baseline SBP/DBP, mmHg | SBP: <100: 2.9% 110–119: 20.1%, 120–139: 35.4%, 140–159: 26.4%, 160–179: 11.1%, ≥ 180: 4.1% |
SBP: 140–159: 31%*, ≥ 160: 21.7%*; DBP <70: 17.6%*, ≥ 90: 22.0%* |
SBP: <140: 43%, 140–149: 20%, ≥ 150: 37% |
Men: SBP: 135.0 ± 19.0/DBP: 76.4 ± 11.5, Women: SBP: 135.7 ± 20.1/DBP: 75.8 ± 11.4 |
SBP: 162.5 ± 21.3/DBP: 91.7 ± 12.9 | SBP: 148.5 ± 31.7 [for total sample] | Isolated Systolic Hypertension, 25.7% [for those aged ≥ 75] | SBP: 136.0/DBP: 80.1 | SBP: 145/DBP: 80 |
Outcome | CVD mortality | CVD mortality | Stroke incidence | CVD mortality | CVD mortality, CHD and stroke incidence | CVD mortality | CVD incidence | CVD incidence | CHD incidence |
Reference BP category | SBP 120–139 | SBP < 140 | SBP < 140 | SBP < 120 and DBP < 80 | SBP < 130 DBP 85–89 | SBP: 100–119 | SBP < 120 | SBP < 120 and DBP < 80 | SBP: 130–139 and DBP: 80–89 |
BP categories significantly associated with increased outcome | SBP ≥ 180; SBP < 100 in those with CVD history |
SBP ≥ 160 | SBP 140–149 | SBP ≥ 160 DBP ≥ 100 | SBP ≥ 160 DBP ≥ 100 | SBP ≥ 180 (in those aged ≥ 65) | SBP ≥ 150 (in those aged ≥ 75) | SBP ≥ 140, DBP ≥ 90 or on antihypertensive medications (in those aged ≥ 60) | < 110/65 (in those aged 60–94) |
CRELES indicates Costa Rican Longevity and Healthy Aging Study; US, United States; DM, diabetes mellitus; CKD, chronic kidney disease; HT, hypertension; SBP, systolic blood pressure; DBP, diastolic blood pressure; CVD, cardiovascular disease; CHD, coronary heart disease; BP, blood pressure.
The percentages are based on the number of total participants interviewed at baseline. Those of the analyzed sample were not available.
REGARDS indicates REasons for Geographic and Racial Differences in Stroke; TLGS, Tehran Lipid and Glucose Study; LSUHLS, Louisiana State University Hospital-Based Longitudinal Study. For the other abbreviations, please see the first page of Table 1.