Figure 6.

Ferret Antibody Titers and Lung Viral Titer Resulting from ClyA-M2e4xHet rOMVs Immunization

(A) Total IgG anti-M2e titers of ferrets 8 weeks post-prime vaccination. Error bars indicate 95% CI of geometric mean (n = 6 ferrets per group) (*p < 0.01). (B) Lung viral titers of ferrets 3 days post-challenge with influenza strain pdmH1N1 (n = 3 ferrets per group). Lung titers compared using ANOVA followed by comparison to mock CC rOMVs using Bonferroni method of correction (n = 3). Error bars indicate SD of log-transformed egg infectious dose (EID₅₀) per gram of lung tissue (*p < 0.01).