Table 2. Cardiac cellular composition.
| Ref. | CMs | Non-myocyte cells | Species | Dev. stage | Method | Heart location | |||
|---|---|---|---|---|---|---|---|---|---|
| CFs | ECs | SMCs | Other cells | ||||||
| (68) | 62% (αMHC) | 10% (Ddr2) | n.d. | n.d. | n.d. | Mouse | P1 | FACS | Whole heart |
| (68) | 63% (αMHC) | 18% (Ddr2) | n.d. | n.d. | n.d. | Mouse | P15 | FACS | Whole heart |
| (68) | 56% (αMHC) | 27% (Ddr2) | 7% (CD31) | 10% (α-SMA) | n.d. | Mouse | Adult | FACS | Whole heart |
| (68) | 52% (αMHC) | 37% (Ddr2) | 11% non-CM/non-CF population | Mouse | Adult | Mouse | Adult | ||
| (68) | 51% (αMHC) | 37% (Ddr2) | 12% non-CM/non-CF population | Mouse | Adult | Mouse | Adult | ||
| (7) | 31%±4% (WGA) | n.d. | 44%±4% (IB4) | n.d. | 5%±1.5% leucocytes (Lin1 cocktail) | Mouse | Adult | IHC | Ventricles + interventricular septum |
| (7) | 32%±5% (ACTN2) | 13%±2.5% (Pdgfrα-GFP); 13%±3.6% (Col1a1-GFP) | 55%±6% (IB4); 52%±3.9% (DACH1) | 6%±1.1% (Pdgfrβ) (SMCs and pericytes) | 8.5%±1.5% leukocytes (Lin1 cocktail) | Mouse (transgenic: Pdgfrα-GFP or Col1a1-GFP) | Adult | IHC | Left ventricle |
| (68) | 62% (αMHC) | 30% (DDR2) | n.d. | n.d. | n.d. | Rat | P1 | FACS | Whole heart |
| (68) | 30% (αMHC) | 64% (DDR2) | n.d. | n.d. | n.d. | Rat | P15 | FACS | Whole heart |
| (66) | 30–35% | 65–70% (ECs, CFs, pericytes, SMCs, Macrophages) | Rat | ||||||
| (6) | 18%±3% (PCM-1) | 58% mesenchymal cells (non-PCM-1, non UEA-I), (CFs, SMCs, pericytes) | 24%±5% (UEA-I) | see CFs | Human | Adult | IHC | ||
| (6) | 33%±15% (PCM-1) | 43%±10% mesenchymal cells (non-PCM-1, non UEA-I), (CFs, SMCs, pericytes) | 24%±9.5% (UEA-I) | see CFs | Human | Adult | FACS | ||
| (7) | 31%±5.6% (ACTN2) | n.d. | 54%±6.4% (CD31); 51%±2.9% (DACH1) | n.d. | 3%±1.2% leukocytes (CD45) | Human | Adult | IHC | Ventricles + interventricular septum |
Ref., reference; CMs, cardiomyocytes; CFs, cardiac fibroblasts; ECs, endothelial cells; SMCs, smooth muscle cells; dev. stage, developmental stage; GFP, green fluorescent protein; P1, postnatal day 1; P15, postnatal day 15; n.d., not determined; IHC, immunohistochemical analyses; FACS, flow cytometric analysis; TEM, transmission electron microscopy.