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. 2017 Apr 7;10:100. doi: 10.3389/fnmol.2017.00100

FIGURE 4.

FIGURE 4

PF-2545920 increases the excitability of pyramidal neurons in the CA1 region. (A) Representative traces of action potentials (APs), mEPSCs, mIPSCs before and after the perfusion of PF-2545920. (B) Frequency of APs increased significantly in pyramidal neurons after perfusion of PF-2545920 (data are means ± SEM, n = 10, *P < 0.05). (C) Frequency of mEPSC increased significantly after PF-2545920 perfusion (data are means ± SEM, n = 10, **P < 0.01), and its representative cumulative fractions. (D) Amplitude of mEPSC was not altered after PF-2545920 treatment (data are means ± SEM, n = 10, P > 0.05), and its representative cumulative fractions. (E) Data demonstrated no significant difference in the frequency of mIPSCs after PF-2545920 treatment (data are means ± SEM, n = 10, P > 0.05), and its representative cumulative fractions. (F) Data revealed no significant difference in the amplitude of mIPSC after PF-2545920 treatment (data are means ± SEM, n = 10, P > 0.05), and its representative cumulative fractions.