Table 2.

Comparison of INTERACT-II versus ATACH-II trials.

	Randomization	Treatment group	Control group	Outcome
INTERACT-II	All within 6 h of symptom onset; 48% systolic blood pressure (SBP) > 180 mmHg	Target SBP < 180 mmHg within 1 h after randomization	Target SBP < 140 mmHg with agents of physician’s choosing	No significant reduction in modified Rankin Scale (mRS) score at 3 months
ATACH-II	All within 4.5 h of symptom onset; SBP > 180 mmHg	Maintain SBP 140–179 mmHg during 24 h after randomization	Maintain SBP 110–139 mmHg during 24 h after randomization with first-line nicardipine and second-line labetalol	No significant reduction in mRS score at 3 months