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. 2017 Apr 7;11:18. doi: 10.3389/fnsys.2017.00018

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Copyright © 2017 Mujica-Parodi, Cha and Gao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic control system, tuned for fMRI data. (A) A schematic control system is structured as a negative feedback loop, with both excitatory and inhibitory components. Circuit-wide dynamics change as a function of lag and connection strength (“connectivity”) between nodes, resulting from variation in synaptic plasticity and/or neurotransmitter/receptor density. (B) Outputs from the model produce waveforms comparable to canonical hemodynamic response function typical for fMRI (here, shown for impulse stimulus).