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Reduction of selected target genes in Ets1−/− B cells. (A) Analysis of Blimp1 expression in lipopolysaccharide-stimulated Ets1+/+, Ets1−/−, and Ets1−/−Prdm1+/gfp B cells. The location of the full-length wild-type and the truncated proteins is indicated on the panel. (B) ELISPOT analysis of the numbers of IgM- and IgG-secreting cells in the spleens of unchallenged mice of the indicated genotypes (n = 4–5 for each genotype). *p < 0.05, **p < 0.01, and ***p < 0.001.
