Table 1.
Drug interactions of FLC and ABH against Candida spp. in vitro.
| Drugs | Isolatesa | MIC (μg/mL)b | FICI model | ||||
|---|---|---|---|---|---|---|---|
| FLC | FLCcomb | ABH | ABHcomb | FICIc | Interpretation | ||
| CA4 (S) | 1 | 0.0313 | >512 | 512 | 1.031 | No interaction | |
| CA8 (S) | 2 | 0.25 | >512 | 512 | 1.125 | No interaction | |
| CA10 (R) | >512 | 2 | 512 | 128 | 0.254 | Synergism | |
| CA16 (R) | >512 | 2 | 512 | 128 | 0.254 | Synergism | |
| CG1 (S) | 16 | 0.25 | 512 | 512 | 1.016 | No interaction | |
| FLC+ABH | CG8 (S) | 32 | 16 | 512 | 256 | 1.000 | No interaction |
| CG2 (R) | 128 | 32 | 512 | 256 | 0.750 | No interaction | |
| CG3 (R) | 128 | 0.5 | 512 | 512 | 1.004 | No interaction | |
| CK2 (S) | 16 | 8 | 512 | 512 | 1.500 | No interaction | |
| CK3 (S) | 32 | 2 | 512 | 512 | 1.063 | No interaction | |
| CK9 (R) | 64 | 32 | 512 | 256 | 1.000 | No interaction | |
| CK10 (R) | 256 | 32 | 1024 | 512 | 0.625 | No interaction | |
a
Twelve isolates with different susceptibilities involved three Candida spp. CA, Candida albicans; CG, Candida glabrata; CK, Candida krusei.
b
MICs denote the MIC80 of each drug alone or in combination (comb) against the isolates and are shown as the median of three independent experiments; FLC, fluconazole; ABH, ambroxol hydrochloride; S, susceptible; R, resistant.
c
The FICI value is the median of three independent experiments; FICI ≤ 0.5 for synergism, FICI > 4.0 for antagonism and 0.5 < FICI ≤ 4.0 for no interaction.