Fig. 2.

MiR-181a regulated the proliferation and invasion of HCC cells. a Relative expression level of miR-181a in HCC cell lines with high or low metastatic capacity and normal liver cells. b The proliferation of HCCLM3 cells with strong metastatic capacity was reduced after knockdown of miR-181a. c The proliferation of Huh7 cells with weak metastatic capacity was increased after the overexpression of miR-181a. d and e Representative micrographs of wound healing assay of HCCLM3 and Huh7 cells stably expressing miR-181a. f The effects of miR-181a overexpression or knockdown on invasion of HCCLM3 or Huh7 cells were analyzed using Transwell assays. HCC, hepatocellular carcinoma. All values are mean ± SD. * vs inhibitor NC, p < 0.05. ** vs inhibitor NC, p < 0.01