Table 2.
Median (IQR) SF-36 Physical and Mental Component Summary scores by respondent characteristic (n = 108)
| Characteristic | SF-36 PCS | p-value | SF-36 MCS | p-value |
|---|---|---|---|---|
| Age | 0.03 | 0.04 | ||
| 13–17 | 86.3 (64.8, 95.7) | 79.5 (64.6, 85.7) | ||
| 18–25 | 75.1 (59.0, 87.1) | 73.4 (58.6, 78.9) | ||
| Gender | 0.12 | 0.10 | ||
| Male | 83.0 (59.0, 94.5) | 76.8 (59.6, 85.7) | ||
| Female | 78.9 (64.8, 86.0) | 71.4 (64.6, 76.4) | ||
| Race | 0.02 | 0.94 | ||
| White | 83.6 (65.7, 94.3) | 75.9 (59.6, 84.3) | ||
| Non-whitea | 62.6 (48.3, 84.8) | 74.3 (64.6, 85.7) | ||
| Ethnicity | 0.18 | 0.73 | ||
| Hispanic | 71.9 (59.3, 81.5) | 77.0 (67.0, 82.1) | ||
| Non-Hispanic | 83.0 (61.1, 94.2) | 75.2 (59.6, 84.8) | ||
| Health insuranceb | 0.13 | 0.21 | ||
| Medicaid or VA onlyc | 79.4 (56.0, 86.4) | 75.9 (64.6, 85.7) | ||
| Commercial only | 86.2 (65.0, 95.7) | 78.8 (65.0, 84.3) | ||
| Both | 71.0 (60.8, 77.7) | 72.9 (59.3, 81.3) | ||
| Insured, type unknown | 83.7 (69.6, 91.8) | 64.3 (54.6, 86.3) | ||
| Uninsured | 63.0 (41.4, 90.5) | 61.8 (42.9, 69/3) | ||
| Mother’s education level | 0.19 | 0.71 | ||
| Bachelor’s degree or higher | 86.1 (65.7, 95.5) | 75.7 (60.4, 85.4) | ||
| Less than Bachelor’s degree | 80.1 (58.1, 91.0) | 75.5 (59.6, 84.3) | ||
| Father’s education level | 0.10 | 0.46 | ||
| Bachelor’s degree or higher | 88.3 (67.4, 95.5) | 76.4 (58.6, 87.1) | ||
| Less than Bachelor’s degree | 79.8 (58.1, 91.0) | 75.4 (60.4, 82.9) | ||
| Bleeding disorder | 0.78 | 0.34 | ||
| Hemophilia A | 81.2 (58.1, 94.5) | 76.4 (59.3, 85.7) | ||
| Hemophilia B | 81.7 (73.2, 88.5) | 76.1 (65.0, 81.8) | ||
| von Willebrand | 80.5 (64.8, 86.2) | 70.0 (64.6, 76.4) | ||
| Severity | 0.98 | 0.37 | ||
| Mild | 81.6 (65.0, 91.7) | 73.2 (61.8, 78.6) | ||
| Moderate | 86.0 (64.0, 88.6) | 75.4 (60.4, 87.1) | ||
| Severe | 79.8 (58.1, 94.3) | 76.4 (59.6, 85.7) | ||
| Inhibitor development | <0.01 | 0.16 | ||
| Ever | 69.0 (45.0, 85.2) | 73.4 (56.8, 83.9) | ||
| Never | 86.1 (67.9, 94.5) | 78.2 (64.6, 86.4) | ||
| Treatment regimen | 0.99 | 0.13 | ||
| On-demand | 81.9 (66.2, 91.7) | 72.9 (59.3, 78.9) | ||
| Prophylaxis | 81.2 (58.1, 94.5) | 77.1 (60.4, 85.7) | ||
| Chronic paind | <0.0001 | 0.01 | ||
| None to mild | 87.1 (75.5, 95.5) | 77.1 (64.6, 86.8) | ||
| Moderate to severe | 59.0 (45.0, 74.5) | 72.9 (56.8, 78.8) | ||
| Clotting factor adherencee | 0.24 | 0.04 | ||
| Adherent | 82.6 (64.8, 95.5) | 76.4 (64.6, 84.3) | ||
| Non-adherent | 79.0 (55.5, 90.5) | 68.2 (48.6, 78.6) |
aMost (73%) of non-white respondents were black or African American, 14% were mixed race, 9% were Asian, and 5% were American Indian or Alaskan Native
b n = 78, two participants answered ‘Don’t Know’ to whether or not they had health insurance and were not included
cOnly two participants had VA only insurance, the others had Medicaid only
dChronic Pain was measured using the revised Faces Pain Scale (FPS-R) and was dichotomized as FPS-R < 4 (i.e., ‘mild’ or ‘no pain) and FPS-R ≥ 4 (i.e., ‘moderate’ to ‘worst pain possible’)
eAdherence was assessed using the Validated Hemophilia Regimen Treatment Adherence Scale (VERITAS)-Pro and VERITAS-PRN for prophylactic and on-demand participants, respectively. The cutoff for non-adherent prophylactic participants was a total VERITAS-Pro score ≥57, as established previously by Duncan and colleagues [25]. This value was chosen because the VERITAS-Pro cutoff was approximately the 75th percentile of all responses
SF-36 36-Item Short Form Health Survey, MCS Mental Component Summary, PCS Physical Component Summary