Table 2. D-serine potencies (IC 50 or EC 50) and efficacies (%) at GluD2-Lc D1–D2 hinge region and binding site mutants determined by two-electrode voltage clamp electrophysiology in Xenopus oocytes.
| Protein | IC50 (μM) [EC50 (μM) for GluN1/GluN2A] | n | D-serine efficacy (%) | n | |
|---|---|---|---|---|---|
| Mean | 95% confidence interval | Mean ± SEM | |||
| GluD2-Lc | 154 | 138–173 | 11 | 46.2 ± 1.9 | 30 |
| GluN1-1a (with GluN2A) | 1.35 | 1.26–1.45 | 8 | n/a* | |
| GluD2-Lc-(H)GluN1 | 1.19 | 0.84–1.69 | 6 | 12.9 ± 0.8 | 30 |
| GluD2-Lc-(HS1)GluN1 | 129 | 100–165 | 9 | 29.1 ± 1.1 | 20 |
| GluD2-Lc-(HS2)GluN1 | n/a** | n/a** | 0.9 ± 0.4 | 20 | |
| GluD2-Lc(D542Y)-(HS2)GluN1 | n/a** | n/a** | –3.4 ± 0.5 | 20 | |
| GluD2-Lc(Y543Q)-(HS2)GluN1 | 10.5 | 8.5–13.0 | 8 | 24.1 ± 0.4 | 20 |
| GluD2-Lc(S544G)-(HS2)GluN1 | 47.9 | 41.4–55.6 | 8 | 40.6 ± 0.5 | 20 |
| GluD2-Lc(Y496F) | 158 | 141–176 | 11 | 43.5 ± 2.0 | 20 |
| GluD2-Lc(Y543Q) | 81.5 | 73.4–90.4 | 11 | 36.2 ± 0.6 | 20 |
| GluD2-Lc(A686S) | 1020 | 911–1143 | 8 | 43.9 ± 0.7 | 20 |
| GluD2-Lc(Y770F) | 18.5 | 17.1–20.0 | 8 | 59.9 ± 1.7 | 20 |
*Efficacy cannot be calculated for an excitatory response.
**No response to D-serine.