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. 2017 Feb 10;24(4):717–730. doi: 10.1038/cdd.2017.5

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/

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DLX3-dependent regulation of epidermal homeostasis-related signaling pathways. (a) Heatmaps showing the DLX3-dependent upregulation of the 'Regulation of Transcription' and 'Wnt Signaling' pathways between DLX3cKO and WT skin treated with GF109203X or acetone (control). Bottom: Heatmaps showing the DLX3-dependent downregulation of the 'Phosphatase Activity' and 'Cell Adhesion' signaling pathways between DLX3cKO and WT skin treated with TPA or GF109203X or acetone (control). Expression values are colored based on their z-score after normalization across treatments. (b) Schematic representation by Venny diagrams of the significantly upregulated (left) or downregulated (right) genes in DLX3cKO skin after treatment with GF109203X prior to TPA (GF-TPA), TPA or acetone (control). Top significant GO Biological Process (BP) terms are indicated in tables: GF-TPA unique (orange), TPA unique (light blue) and GF-TPA and TPA common (green)